After all, in spite of opinion, prejudice or error, Time willfix the real value upon this discovery, and determine whetherI have imposed upon myself and others, or contributed to thebenefit of science and mankind.
— William Withering, 1785
Since 1785, when Sir William Withering published his treatiseon the use of foxglove (see Figure), our perspective on theuse of digitalis has continued to change. Withering believedthat digitalis had a diuretic effect in patients with a weakand irregular pulse who had edema.
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Digoxin for the Treatment of Heart Failure
Moulias S., Tigoulet F., Meaume S., Hudson M., Pilote L., Hallberg P., Michaëlsson K., Melhus H., Rathore S. S., Krumholz H. M.
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N Engl J Med 2003;
348:661-663, Feb 13, 2003.
Correspondence
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