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Correspondence
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Volume 347:1456 October 31, 2002 Number 18
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Fulminant Hepatitis E in Japan

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To the Editor: Hepatitis E virus (HEV) is the leading cause of water-borne epidemics of hepatitis in many developing countries in Asia and Africa, where high mortality has been reported among infected pregnant women.1 Recently, it has become clear that sporadic hepatitis E occurs in persons in industrialized countries who have no evidence of exposure to HEV strains from countries where the infection is endemic.1,2,3 However, the contribution of HEV to the development of fulminant hepatitis in industrialized nations is unclear.

To investigate whether HEV might be a cause of fulminant hepatitis in Japan, we conducted a study involving 18 . . . [Full Text of this Article]


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