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Previous Volume 347:1512-1520 November 7, 2002 Number 19 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text PDF PDA Full Text Editorial by Varmus, H. Letters Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited PubMed Citation

Humans have known for millennia that heredity affects health.¹ However, Mendel's seminal contribution to the elucidation of the mechanisms by which heredity affects phenotype occurred less than 150 years ago, and Garrod began applying this knowledge to human health only at the start of the past century. For most of the 20th century, many medical practitioners viewed genetics as an esoteric academic specialty; that view is now dangerously outdated.

The Advent of Genomic Medicine

The recent completion of the draft sequence of the human genome^2,3 and related developments have increased interest in genetics, but confusion remains among health professionals and the public about the role . . . [Full Text of this Article]

The Human Genome

Monogenic Conditions

Types of Mutation

Genes in Common Disease

Variation in the Human Genome

Conclusions

Source Information

From the National Human Genome Research Institute, National Institutes of Health, Bethesda, Md.

Address reprint requests to Dr. Guttmacher at Bldg. 31, Rm. 4B09, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892-2152, or at guttmach@mail.nih.gov.

Related Letters:

Genomic Medicine
Weed H. G., Medow M. A., Guttmacher A. E., Collins F. S.
Extract | Full Text | PDF  
N Engl J Med 2003; 348:759-760, Feb 20, 2003. Correspondence

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