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Volume 347:1626 November 14, 2002 Number 20
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Anxiety and Genetically Engineered Mice

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by Freedman, R.
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To the Editor: Freedman's conclusions about the stability of timidity in genetically engineered mice (July 18 issue)1 are not supported by longitudinal studies in children. It is unjustifiable to suggest that temperamentally inhibited children are destined to a life of anxiety disorders.

In their landmark study, Chess and Thomas followed a cohort of children from shortly after birth into their 20s.2 They found that what matters to the adjustment of children is not just the children's personality traits themselves, but also their interaction or "fit" with the attitudes and management of the caregivers. Moreover, there is ample evidence that the . . . [Full Text of this Article]



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