Stroke is the second leading cause of death and the most commoncause of disability in the world. Its incidence is rising withincreasing life expectancy. To relieve the heavy burden of stroke,we need to understand the mechanisms that will form the basisof improved prevention and treatment. Ischemic or hemorrhagicstroke is the outcome of a number of different pathophysiologicalmechanisms, which include cardioembolism, prothrombotic states,and disease of large and small cerebral vessels. Epidemiologicstudies involving twins, siblings, or families have found evidenceof a genetic influence on stroke. From the clinical point ofview, it is . . . [Full Text of this Article]
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Genetics of Stroke
Meschia J. F., Brott T. G., Brown R. D. Jr., the Siblings with Ischemic Stroke Study Investigators , Ngeh J. K.T., Toh V. K.L.
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N Engl J Med 2003;
348:1407, Apr 3, 2003.
Correspondence
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