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Previous Volume 347:1834-1840 December 5, 2002 Number 23 Next

	Full Text PDF PDA Full Text PowerPoint Slide Set Perspective by Cain, M. E. Editorial by Falk, R. H. Letters Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited PubMed Citation

ABSTRACT

Background Maintenance of sinus rhythm is the main therapeutic goal in patients with atrial fibrillation. However, recurrences of atrial fibrillation and side effects of antiarrhythmic drugs offset the benefits of sinus rhythm. We hypothesized that ventricular rate control is not inferior to the maintenance of sinus rhythm for the treatment of atrial fibrillation.

Methods We randomly assigned 522 patients who had persistent atrial fibrillation after a previous electrical cardioversion to receive treatment aimed at rate control or rhythm control. Patients in the rate-control group received oral anticoagulant drugs and rate-slowing medication. Patients in the rhythm-control group underwent serial cardioversions and received antiarrhythmic drugs and oral anticoagulant drugs. The end point was a composite of death from cardiovascular causes, heart failure, thromboembolic complications, bleeding, implantation of a pacemaker, and severe adverse effects of drugs.

Results After a mean (±SD) of 2.3±0.6 years, 39 percent of the 266 patients in the rhythm-control group had sinus rhythm, as compared with 10 percent of the 256 patients in the rate-control group. The primary end point occurred in 44 patients (17.2 percent) in the rate-control group and in 60 (22.6 percent) in the rhythm-control group. The 90 percent (two-sided) upper boundary of the absolute difference in the primary end point was 0.4 percent (the prespecified criterion for noninferiority was 10 percent or less). The distribution of the various components of the primary end point was similar in the rate-control and rhythm-control groups.

Conclusions Rate control is not inferior to rhythm control for the prevention of death and morbidity from cardiovascular causes and may be appropriate therapy in patients with a recurrence of persistent atrial fibrillation after electrical cardioversion.

Source Information

From the Department of Cardiology (I.C.V.G., V.E.H., H.J.G.M.C.) and the Trial Coordination Center (T.K.), University Hospital, Groningen; Rijnstate Hospital, Arnhem (H.A.B.); St. Antonius Hospital, Nieuwegein (J.H.K.); Free University Medical Center, Amsterdam (O.K.); Hospital Midden-Twente, Hengelo (S.A.S.); Twenteborg Hospital, Almelo (J.I.D.); Medisch Spectrum Twente, Enschede (A.J.M.T.); and Academic Medical Center, Amsterdam (J.G.P.T.) — all in the Netherlands.

Address reprint requests to Dr. Van Gelder at the Department of Cardiology, Thoraxcenter, University Hospital Groningen, P.O. Box 30.001, 9700 RB Groningen, the Netherlands, or at i.c.van.gelder{at}thorax.azg.nl.

Full Text of this Article

Related Letters:

Atrial Fibrillation — Rate versus Rhythm Control
Kühlkamp V., Seipel L., Healy E. C., Bhaskarabhatla K., Manning W. J., Wyse D. G., Van Gelder I. C., Crijns H. J.G.M.
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N Engl J Med 2003; 348:1284-1286, Mar 27, 2003. Correspondence

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• Betts, T R (2006). Rhythm control strategies for "symptomatic" persistent atrial fibrillation: is achieving sinus rhythm enough?. Heart 92: 1189-1190 [Abstract] [Full Text]  
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• Fuster, V., Ryden, L. E., Cannom, D. S., Crijns, H. J., Curtis, A. B., Ellenbogen, K. A., Halperin, J. L., Le Heuzey, J.-Y., Kay, G. N., Lowe, J. E., Olsson, S. B., Prystowsky, E. N., Tamargo, J. L., Wann, S. (2006). ACC/AHA/ESC 2006 Guidelines for the Management of Patients With Atrial Fibrillation: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Revise the 2001 Guidelines for the Management of Patients With Atrial Fibrillation) Developed in Collaboration With the European Heart Rhythm Association and the Heart Rhythm Society . J Am Coll Cardiol 48: e149-e246 [Full Text]  
• Fuster, V., Ryden, L. E., Cannom, D. S., Crijns, H. J., Curtis, A. B., Ellenbogen, K. A., Halperin, J. L., Le Heuzey, J.-Y., Kay, G. N., Lowe, J. E., Olsson, S. B., Prystowsky, E. N., Tamargo, J. L., Wann, S., ACC/AHA TASK FORCE MEMBERS, , Smith, S. C. Jr, Jacobs, A. K., Adams, C. D., Anderson, J. L., Antman, E. M., Halperin, J. L., Hunt, S. A., Nishimura, R., Ornato, J. P., Page, R. L., Riegel, B., ESC COMMITTEE FOR PRACTICE GUIDELINES, , Priori, S. G., Blanc, J.-J., Budaj, A., Camm, A. J., Dean, V., Deckers, J. W., Despres, C., Dickstein, K., Lekakis, J., McGregor, K., Metra, M., Morais, J., Osterspey, A., Tamargo, J. L., Zamorano, J. L. (2006). ACC/AHA/ESC 2006 Guidelines for the Management of Patients With Atrial Fibrillation: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Revise the 2001 Guidelines for the Management of Patients With Atrial Fibrillation): Developed in Collaboration With the European Heart Rhythm Association and the Heart Rhythm Society. Circulation 114: e257-e354 [Full Text]  
• Fuster, V., Ryden, L. E., Cannom, D. S., Crijns, H. J., Curtis, A. B., Ellenbogen, K. A., Halperin, J. L., Le Heuzey, J.-Y., Kay, G. N., Lowe, J. E., Olsson, S. B., Prystowsky, E. N., Tamargo, J. L., Wann, S., ACC/AHA TASK FORCE MEMBERS, , Smith, S. C. Jr, Jacobs, A. K., Adams, C. D., Anderson, J. L., Antman, E. M., Halperin, J. L., Hunt, S. A., Nishimura, R., Ornato, J. P., Page, R. L., Riegel, B., ESC COMMITTEE FOR PRACTICE GUIDELINES, , Priori, S. G., Blanc, J.-J., Budaj, A., Camm, A. J., Dean, V., Deckers, J. W., Despres, C., Dickstein, K., Lekakis, J., McGregor, K., Metra, M., Morais, J., Osterspey, A., Tamargo, J. L., Zamorano, J. L. (2006). ACC/AHA/ESC 2006 Guidelines for the Management of Patients With Atrial Fibrillation--Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Revise the 2001 Guidelines for the Management of Patients With Atrial Fibrillation): Developed in Collaboration With the European Heart Rhythm Association and the Heart Rhythm Society. Circulation 114: 700-752 [Full Text]  
• Authors/Task Force Members, , Fuster, V., Ryden, L. E., Cannom, D. S., Crijns, H. J., Curtis, A. B., Ellenbogen, K. A., Halperin, J. L., Le Heuzey, J.-Y., Kay, G. N., Lowe, J. E., Olsson, S. B., Prystowsky, E. N., Tamargo, J. L., Wann, S., ESC Committee for Practice Guidelines, , Priori, S. G., Blanc, J.-J., Budaj, A., Camm, A. J., Dean, V., Deckers, J. W., Despres, C., Dickstein, K., Lekakis, J., McGregor, K., Metra, M., Morais, J., Osterspey, A., Tamargo, J. L., Zamorano, J. L., ACC/AHA (Practice Guidelines) Task Force Members, , Smith, S. C. Jr, Jacobs, A. K., Adams, C. D., Anderson, J. L., Antman, E. M., Halperin, J. L., Hunt, S. A., Nishimura, R., Ornato, J. P., Page, R. L., Riegel, B. (2006). ACC/AHA/ESC 2006 guidelines for the management of patients with atrial fibrillation executive summary: A report of the American College of Cardiology/American Heart Association Task Force on practice guidelines and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Revise the 2001 Guidelines for the Management of Patients with Atrial Fibrillation) Developed in collaboration with the European Heart Rhythm Association and the Heart Rhythm Society. Eur Heart J 27: 1979-2030 [Full Text]  
• Stulak, J. M., Dearani, J. A., Daly, R. C., Zehr, K. J., Sundt, T. M. III, Schaff, H. V. (2006). Left Ventricular Dysfunction in Atrial Fibrillation: Restoration of Sinus Rhythm by the Cox-Maze Procedure Significantly Improves Systolic Function and Functional Status. Ann. Thorac. Surg. 82: 494-501 [Abstract] [Full Text]  
• Kollar, A., Lick, S. D., Vasquez, K. N., Conti, V. R. (2006). Relationship of Atrial Fibrillation and Stroke After Coronary Artery Bypass Graft Surgery: When is Anticoagulation Indicated?. Ann. Thorac. Surg. 82: 515-523 [Abstract] [Full Text]  
• Holmqvist, F., Stridh, M., Waktare, J. E.P., Roijer, A., Sornmo, L., Platonov, P. G., Meurling, C. J. (2006). Atrial fibrillation signal organization predicts sinus rhythm maintenance in patients undergoing cardioversion of atrial fibrillation. Europace 8: 559-565 [Abstract] [Full Text]  
• Hu, C L, Jiang, H, Tang, Q Z, Zhang, Q H, Chen, J B, Huang, C X, Li, G S (2006). Comparison of rate control and rhythm control in patients with atrial fibrillation after percutaneous mitral balloon valvotomy: a randomised controlled study. Heart 92: 1096-1101 [Abstract] [Full Text]  
• Chan, P. S., Vijan, S., Morady, F., Oral, H. (2006). Cost-Effectiveness of Radiofrequency Catheter Ablation for Atrial Fibrillation. J Am Coll Cardiol 47: 2513-2520 [Abstract] [Full Text]  
• Bunch, T. J., Mahapatra, S., Bruce, G. K., Johnson, S. B., Miller, D. V., Horne, B. D., Wang, X.-L., Lee, H.-C., Caplice, N. M., Packer, D. L. (2006). Impact of Transforming Growth Factor-{beta}1 on Atrioventricular Node Conduction Modification by Injected Autologous Fibroblasts in the Canine Heart. Circulation 113: 2485-2494 [Abstract] [Full Text]  
• Hemels, M. E.W., Gu, Y. L., Tuinenburg, A. E., Boonstra, P. W., Wiesfeld, A. C.P., van den Berg, M. P., Van Veldhuisen, D. J., Van Gelder, I. C. (2006). Favorable long-term outcome of maze surgery in patients with lone atrial fibrillation.. Ann. Thorac. Surg. 81: 1773-1779 [Abstract] [Full Text]  
• Elesber, A. A., Rosales, A. G., Herges, R. M., Shen, W.-K., Moon, B. S., Malouf, J. F., Ammash, N. M., Somers, V., Hodge, D. O., Gersh, B. J., Hammill, S. C., Friedman, P. A. (2006). Relapse and mortality following cardioversion of new-onset vs. recurrent atrial fibrillation and atrial flutter in the elderly. Eur Heart J 27: 854-860 [Abstract] [Full Text]  
• Rienstra, M., Van Gelder, I. C., Hagens, V. E., Veeger, N. J.G.M., Van Veldhuisen, D. J., Crijns, H. J.G.M., for the RACE Investigators, (2006). Mending the rhythm does not improve prognosis in patients with persistent atrial fibrillation: a subanalysis of the RACE study. Eur Heart J 27: 357-364 [Abstract] [Full Text]  
• Earley, M. J, Schilling, R. J (2006). Catheter and surgical ablation of atrial fibrillation. Heart 92: 266-274 [Full Text]  
• Regan, C. P., Wallace, A. A., Cresswell, H. K., Atkins, C. L., Lynch, J. J. Jr. (2006). In Vivo Cardiac Electrophysiologic Effects of a Novel Diphenylphosphine Oxide IKur Blocker, (2-Isopropyl-5-methylcyclohexyl) Diphenylphosphine Oxide, in Rat and Nonhuman Primate. J. Pharmacol. Exp. Ther. 316: 727-732 [Abstract] [Full Text]  
• Hemels, M. E.W., Wiesfeld, A. C.P., Inberg, B., Van Dessel, P. F.H.M., Nieuwland, W., Tan, E. S., Mulder, H., Van Veldhuisen, D. J., Van Gelder, I. C. (2006). Right atrial overdrive pacing for prevention of symptomatic refractory atrial fibrillation.. Europace 8: 107-112 [Abstract] [Full Text]  
• Hall, M C S, Todd, D M (2006). Modern management of arrhythmias. Postgrad. Med. J. 82: 117-125 [Abstract] [Full Text]  
• Stabile, G., Bertaglia, E., Senatore, G., De Simone, A., Zoppo, F., Donnici, G., Turco, P., Pascotto, P., Fazzari, M., Vitale, D. F. (2006). Catheter ablation treatment in patients with drug-refractory atrial fibrillation: a prospective, multi-centre, randomized, controlled study (Catheter Ablation For The Cure Of Atrial Fibrillation Study). Eur Heart J 27: 216-221 [Abstract] [Full Text]  
• Boos, C. J., Anderson, R. A., Lip, G. Y.H. (2006). Is atrial fibrillation an inflammatory disorder?. Eur Heart J 27: 136-149 [Abstract] [Full Text]  
• Lo, G K, Fatovich, D M, Haig, A D (2006). Biphasic cardioversion of acute atrial fibrillation in the emergency department. Emerg. Med. J. 23: 51-53 [Abstract] [Full Text]  
• Kalus, J. S., Coleman, C. I., White, C. M. (2006). The Impact of Suppressing the Renin-Angiotensin System on Atrial Fibrillation. J Clin Pharmacol 46: 21-28 [Abstract] [Full Text]  
• Sundt, T. M., Gersh, B. J. (2005). Making Sense of the Maze: Which Patients With Atrial Fibrillation Will Benefit?. JAMA 294: 2357-2359 [Full Text]  
• Zhang, Y., Yamada, H., Bibevski, S., Zhuang, S., Mowrey, K. A., Wallick, D. W., Oh, S., Mazgalev, T. N. (2005). Chronic Atrioventricular Nodal Vagal Stimulation: First Evidence for Long-Term Ventricular Rate Control in Canine Atrial Fibrillation Model. Circulation 112: 2904-2911 [Abstract] [Full Text]