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Correspondence
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Volume 347:1889-1890 December 5, 2002 Number 23
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Drug Resistance among Patients Recently Infected with HIV

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 by Little, S. J.
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To the Editor: The retrospective analysis by Little et al. (Aug. 8 issue)1 provides further evidence of the transmission of drug-resistant human immunodeficiency virus type 1 (HIV-1)2 and attempts to relate detection of resistant virus before antiretroviral therapy to suboptimal virologic response. However, the authors' recommendations for universal base-line resistance testing and abandonment of empirical treatment are premature.

Ascertainment of base-line viral resistance is not recommended by the current guidelines except in cases of virologic failure or incomplete viral suppression after initial therapy.3 Little et al. did show that the time to viral suppression was shorter and the time to . . . [Full Text of this Article]




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