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Previous Volume 347:1941-1951 December 12, 2002 Number 24 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Peripheral arterial disease, a manifestation of systemic atherosclerosis, affects approximately 8 million to 10 million people in the United States, with an age-adjusted prevalence of 12 percent that increases to 20 percent if only persons older than 70 years are considered.^1,2 Claudication, defined as walking-induced pain in one or both legs (primarily affecting the calves) that does not go away with continued walking and is relieved only by rest, is present in 15 to 40 percent of patients with peripheral arterial disease³ and is associated with a diminished ability to perform daily activities.^3,4,5

The treatment of this condition focuses on . . . [Full Text of this Article]

Functional Benefits of Exercise Training

Potential Mechanisms of Improvement

Formation of Collateral Vessels and Increased Blood Flow

Changes in Microcirculation and Endothelial Function

The Hemorheologic Hypothesis

Changes in Muscle Metabolism and Oxygen Extraction

Inflammation and Muscle Injury

Walking Economy

Atherosclerosis and Prothrombotic Risk Factors

Exercise Prescription

Exercise Combined with Other Treatments

Conclusions

Source Information

From the Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore (K.J.S.); the Section of Vascular Medicine, Divisions of Cardiology (W.R.H., J.G.R.), Geriatrics (W.R.H.), and Internal Medicine (J.G.R.), Department of Medicine, University of Colorado Health Sciences Center, Denver; the Colorado Prevention Center, Denver (W.R.H.); and the Vascular Medicine Program, Cardiovascular Division, Minnesota Vascular Diseases Centers, University of Minnesota Medical School, Minneapolis (A.T.H.).

Address reprint requests to Dr. Stewart at Johns Hopkins Bayview Medical Center, 4940 Eastern Ave., Baltimore, MD 21224, or at kstewart@mail.jhmi.edu.

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