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Previous Volume 347:1978-1980 December 12, 2002 Number 24 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Kiechl and colleagues (July 18 issue)¹ provide interesting evidence that the toll-like receptor 4 (TLR4) 896G (299Gly) polymorphism may confer susceptibility to bacterial infection. As part of ongoing collaborative projects,^2,3,4 we have investigated the role of this polymorphism in a large United Kingdom study of invasive pneumococcal disease and a large West African study of pulmonary tuberculosis. There was no evidence of an association between the TLR4 896G allele and invasive pneumococcal disease or pulmonary tuberculosis (Table 1). These data add to the findings of Read et al.⁵ that the TLR4 896G polymorphism was not . . . [Full Text of this Article]

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