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Volume 347:2077-2079 December 19, 2002 Number 25
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New Strains of Bacteria and Exacerbations of COPD

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 by Anthonisen, N. R.
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 by Sethi, S.
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To the Editor: I find the choice of denominators by Sethi et al. (Aug. 15 issue)1 curious, in that they compare patients with new strains during exacerbations with stable patients without new strains. This appears to be comparing apples and oranges, particularly given the wide range of base-line characteristics in the study population. For example, the forced expiratory volume in one second (FEV1) at base line ranged from 0.47 liter to 4.07 liters, and the FEV1 as a percentage of the predicted value ranged from 15 percent to 99 percent. Furthermore, over the 56-month study period, the number of . . . [Full Text of this Article]


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