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Volume 347:2086 December 19, 2002 Number 25
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Neonatal Hair Analysis as a Biomarker for in Utero Alcohol Exposure

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To the Editor: Alcohol is the most prevalent human teratogen. Fetal alcohol spectrum disorder is estimated to affect up to 1 percent of infants born in North America. The ascertainment of gestational exposure to alcohol is paramount for the diagnosis of the disorder. It is widely recognized that maternal reporting results in underestimates of the prevalence and amount of exposure to alcohol.

Until recently, there have been no objective biologic markers for the detection of long-term in utero exposure to alcohol. Studies in adults have documented that circulating ethanol is transesterified with fatty acids to fatty acid ethyl esters.1 On . . . [Full Text of this Article]


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