To the Editor: Alcohol is the most prevalent human teratogen.Fetal alcohol spectrum disorder is estimated to affect up to1 percent of infants born in North America. The ascertainmentof gestational exposure to alcohol is paramount for the diagnosisof the disorder. It is widely recognized that maternal reportingresults in underestimates of the prevalence and amount of exposureto alcohol.
Until recently, there have been no objective biologic markersfor the detection of long-term in utero exposure to alcohol.Studies in adults have documented that circulating ethanol istransesterified with fatty acids to fatty acid ethyl esters.1On . . . [Full Text of this Article]
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