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Volume 347:2168-2170 December 26, 2002 Number 26
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Regression of Splenic Lymphoma after Treatment of Hepatitis C Virus Infection

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 by Hermine, O.
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To the Editor: The report of Hermine et al. (July 11 issue)1 provides important additional evidence as to the possible role of antiviral therapy for hepatitis C virus (HCV) infection in the treatment of patients with HCV-associated mixed cryoglobulinemia and lymphoma. They report regression of splenic lymphoma with villous lymphocytes and loss of HCV RNA in seven patients with mixed cryoglobulinemia and HCV infection after treatment with interferon. In five of these patients, molecular studies were performed, but none of them showed loss of the monoclonal immunoglobulin gene component.

In 1996, we reported complete remission of low-grade types of non-Hodgkin's . . . [Full Text of this Article]


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