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Correspondence
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Volume 347:218-220 July 18, 2002 Number 3
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Male Cells in Female Recipients of Hematopoietic-Cell Transplants

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by Abkowitz, J. L.
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by Körbling, M.
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To the Editor: Körbling et al. (March 7 issue)1 report that some cytokeratin-positive epidermal cells are of donor origin in recipients of peripheral-blood stem-cell allografts.1 Because of the technical limitations of identifying epidermal cells of donor origin by labeling of Y chromosomes and specific staining of five consecutive 4-µm sections, this result should be interpreted with caution.

Previous studies have suggested that skin could be a homing tissue for chimeric cells during gestation or after organ transplantation2 and showed that female recipients of allogeneic bone marrow transplants had epidermal Langerhans' cells of male-donor origin.3 Epidermal Langerhans' cells belong to the . . . [Full Text of this Article]



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