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Volume 347:230-231 July 25, 2002 Number 4 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The most common nonlethal malformation in the spectrum of neural-tube defects is myelomeningocele. This defect, caused by failure of the neural tube to close completely at about four weeks of gestation, occurs in approximately 1 in 2000 births. The extent and severity of the neurologic deficits (which include motor dysfunction in the legs and lack of bladder and bowel control) depend on the location of the lesion along the neuroaxis; the cord below the lesion is dysplastic. Myelomeningocele is often associated with the type II Chiari hindbrain malformation, a downward displacement of the cerebellar vermis into the cervical spinal canal, . . . [Full Text of this Article]

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