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Correspondence
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Volume 347:374 August 1, 2002 Number 5
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Treatment of High-Grade Vaginal Intraepithelial Neoplasia with Imiquimod Cream

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To the Editor: Primary invasive carcinoma of the vagina is rare, accounting for less than 3 percent of malignant tumors of the female genital tract. Vaginal intraepithelial neoplasia, a precursor of invasive vaginal carcinoma, is even less common.1 Cytologic screening for vaginal tumors is not useful, unless there is a history of neoplasia of the lower genital tract.2,3 We treated three women with high-grade vaginal intraepithelial neoplasia by applying 5 percent imiquimod cream vaginally. Imiquimod induces the secretion of interferon-{alpha}, interleukin-12, and tumor necrosis factor {alpha} from mononuclear cells.

All three women were positive for the high-risk type of human . . . [Full Text of this Article]



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