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Previous Volume 347:417-429 August 8, 2002 Number 6 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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In the decades since the major forms of idiopathic inflammatory bowel disease were defined on the basis of clinical manifestations, investigators have been challenged to identify the fundamental pathophysiologic processes underlying these enigmatic disorders, and clinicians have struggled to provide effective therapy for the often dismaying clinical manifestations. Clinical experience has led to the generally accepted notion that Crohn's disease and ulcerative colitis are distinct, if not discrete, entities. However, whether these are fundamentally different diseases or part of a mechanistic continuum remains an unanswered question, with both conceptual and practical management implications.

Etiology and Pathophysiology

Inflammatory bowel disease is thought to result . . . [Full Text of this Article]

Genetic Factors

Environmental Precipitants and Disease Cofactors

Immune Response and Inflammatory Pathways

Treatment

5-Aminosalicylic Acid

Corticosteroids

Immunosuppressive and Immunoregulatory Agents

Anti-TNF Therapy

Antibiotics and Probiotics

Investigational Agents

Conclusions

Source Information

From the Gastrointestinal Unit and the Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital and Harvard Medical School, Boston.

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Extract | Full Text | PDF  
N Engl J Med 2002; 347:1982-1984, Dec 12, 2002. Correspondence

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