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A 48-year-old man was admitted to the Ambulatory Disease Service of the Massachusetts Eye and Ear Infirmary because of severe chronic oral lesions.
For several years, the patient had taken ibuprofen because of pain in the back and knees. Sixteen months before admission, he stopped taking the ibuprofen before undergoing surgery for cervical disk disease. The procedure was followed by the development of left ulnar pain, for which he began taking oxycodoneacetaminophen. About three months later, swelling and erythema developed in the right leg. The soles of both feet became red and cracked, and the fingernails and toenails dropped off
Differential Diagnosis
Physical Causes
Aphthous Stomatitis and Related Conditions
Herpetic Stomatitis and Herpetiform Aphthous Stomatitis
Major Aphthous Stomatitis
Behçet's Syndrome
Autoimmune Disorders
Lichen Planus
Pemphigoid
Pemphigus Vulgaris
Other Autoimmune Conditions
Clinical Diagnosis
Dr. George T. Gallagher's Diagnosis
Pathological Discussion
Anatomical Diagnosis
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