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Previous Volume 347:452-453 August 8, 2002 Number 6 Next

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To the Editor: Treatment of chronic lymphocytic leukemia (CLL) with fludarabine results in a higher remission rate and longer progression-free survival than do alkylating agents.¹ Patients who have no response to fludarabine have a dismal prognosis, with a median survival of 10 months.² In these patients the anti–CD52 antibody alemtuzumab (Campath-1H, MabCampath) has recently shown promising results, with an overall response rate of 33 percent.³ The molecular mechanisms of its action and the biologic factors associated with the clinical response are not well defined.

A 72-year-old woman was given a diagnosis of CLL, Binet stage A, in August 1997. Because . . . [Full Text of this Article]

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