Viruses are particularly troublesome pathogens in transplantrecipients. Viral infections enhance susceptibility to opportunisticinfection both by causing tissue injury and by contributingto systemic immunosuppression.1 Such infections increase therate of graft rejection and the risk that cancer will develop.The problem of viral infection in transplantation reflects theintricate balance between lifelong viral infection in tissues,the host's antiviral immune function, and the level of immunosuppressionrequired to maintain graft function.
The likelihood that latent viral infection will be activatedis a function of the microbiologic features of the specificvirus, the presence of stimuli for the activation . . . [Full Text of this Article]
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