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Previous Volume 347:576-580 August 22, 2002 Number 8 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Mammalian mitochondrial DNA (mtDNA) is thought to be strictly maternally inherited.^1,2 Sperm mitochondria disappear in early embryogenesis by selective destruction, inactivation, or simple dilution by the vast surplus of oocyte mitochondria.³

Very small amounts of paternally inherited mtDNA have been detected by the polymerase chain reaction (PCR) in mice after several generations of interspecific backcrosses.⁴ Studies of such hybrids and of mouse oocytes microinjected with sperm support the hypothesis that sperm mitochondria are targeted for destruction by nuclear-encoded proteins.^5,6,7 We report the case of a 28-year-old man with mitochondrial myopathy due to a novel 2-bp mtDNA deletion in the ND2 . . . [Full Text of this Article]

Case Report

Methods

Results

Discussion

Source Information

From the Department of Clinical Genetics (M.S.) and the Department of Neurology and the Copenhagen Muscle Research Center (J.V.), University Hospital Rigshospitalet, Copenhagen, Denmark.

Address reprint requests to Dr. Schwartz at the Department of Clinical Genetics, Rigshospitalet 4062, Blegdamsvej 9, Copenhagen DK 2100, Denmark, or at schwartz@rh.dk.

Related Letters:

Paternal Inheritance of Mitochondrial DNA
Gustafson A. W., Heckerling P. S., Vissing J., Schwartz M.
Extract | Full Text | PDF  
N Engl J Med 2002; 347:2081-2082, Dec 19, 2002. Correspondence

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