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Previous Volume 347:613-614 August 22, 2002 Number 8 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text PDF PDA Full Text Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited Related Article by Rosen, F. S. Related Article by Hacein-Bey-Abina, S. Related Article by Hacein-Bey-Abina, S. PubMed Citation

To the Editor: Correction of X-linked severe combined immunodeficiency by infusion of autologous CD34+ stem cells transduced with retrovirus containing common chain, reported by Hacein-Bey-Abina et al. (April 18 issue),¹ is a milestone in medicine. We used a different therapy with a similarly good outcome.

X-linked severe combined immunodeficiency was diagnosed in two patients after the initiation of mechanical ventilation for pulmonary failure caused by infections. Immediately after the diagnosis had been made, haploidentical CD34+ peripheral progenitor cells mobilized with granulocyte colony-stimulating factor were isolated to a purity of more than 99 percent.² These cells were infused with no preparative . . . [Full Text of this Article]

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