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Correspondence
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Volume 347:615 August 22, 2002 Number 8
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Sulindac in Familial Adenomatous Polyposis

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by Giardiello, F. M.
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To the Editor: Giardiello et al. (April 4 issue)1 conclude that sulindac does not delay the occurrence or reduce the number or size of colorectal adenomas in patients bearing a mutation of the adenomatous polyposis coli (APC) gene. The authors do not take into account two important factors: the position of the mutation in the germ-line APC gene and the level of expression of the wild-type allele in normal colonic mucosa and in adenomas. In familial adenomatous polyposis, there is a strong correlation between the location of the mutation in the APC gene and the age at onset . . . [Full Text of this Article]



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