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Correspondence
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Volume 348:86-87 January 2, 2003 Number 1
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Linezolid-Induced Lactic Acidosis

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To the Editor: Linezolid is an oxazolidinone antibiotic used to treat a variety of gram-positive infections, including those due to methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci, as well as nocardia species.1,2 Lactic acidosis is an adverse effect that has been associated with other drugs, including metformin and the nucleoside reverse-transcriptase inhibitors,3 but not with linezolid. We report a case in which severe lactic acidosis developed as an adverse effect of linezolid treatment.

A 52-year-old woman presented with fever, chills, and a two-week history of intermittent cough. Computed tomography (CT) of her chest revealed an infiltrate in the right middle lobe, . . . [Full Text of this Article]


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