To the Editor: Linezolid is an oxazolidinone antibiotic usedto treat a variety of gram-positive infections, including thosedue to methicillin-resistant Staphylococcus aureus and vancomycin-resistantenterococci, as well as nocardia species.1,2 Lactic acidosisis an adverse effect that has been associated with other drugs,including metformin and the nucleoside reverse-transcriptaseinhibitors,3 but not with linezolid. We report a case in whichsevere lactic acidosis developed as an adverse effect of linezolidtreatment.
A 52-year-old woman presented with fever, chills, and a two-weekhistory of intermittent cough. Computed tomography (CT) of herchest revealed an infiltrate in the right middle lobe, . . . [Full Text of this Article]
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