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Volume 348:959-960 March 6, 2003 Number 10
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Analgesics for the Treatment of Pain in Children

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by Berde, C. B.
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To the Editor: Berde and Sethna (Oct. 3 issue)1 provide an excellent summary of developmental differences in pharmacology that dictate the appropriate use of analgesics in pediatric patients. However, there are gaps in the data required to support the labeling of drugs for safe and effective use among pediatric subpopulations. There are formidable challenges in designing adequate trials for pain management, including ethical considerations, pain-assessment instruments, and separation of assessments of pain from sedation. In the past, these barriers and a lack of incentives or regulatory requirements contributed to an incomplete understanding of the safe and effective use of analgesics . . . [Full Text of this Article]



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