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Previous Volume 348:1163-1165 March 20, 2003 Number 12 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Platelet activation is central to the formation of thrombus, which precipitates most unstable coronary syndromes. The angiographic severity of coronary stenoses may not predict the occurrence of acute cardiac events, since rupture of atheromatous plaque and subsequent thrombosis in slightly stenosed vessels may underlie many myocardial infarctions. Normally, the intact endothelium prevents platelet activation, but intimal injury associated with endothelial denudation and plaque rupture exposes subendothelial collagen and von Willebrand factor, supporting prompt platelet adhesion and activation. Local platelet activation then promotes the recruitment of platelets and the formation of thrombus.

The importance of platelet-dependent thrombosis has made activated platelets . . . [Full Text of this Article]

Source Information

From the Evans Department of Medicine, Boston University School of Medicine, Boston.

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