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Previous Volume 348:1192 March 20, 2003 Number 12

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Selective Estrogen-Receptor Modulators — Mechanisms of Action and Application to Clinical Practice . There was an error in Figure 2; a corrected figure is shown here.

View larger version (38K): [in this window] [in a new window]   Figure 2. Estrogen-Receptor Action. Each class of SERMs (orange symbols) has a slightly different shape, although all will bind to the estrogen receptor. When it binds to an estrogen, antiestrogen, or SERM, the estrogen receptor undergoes a conformational change that permits its spontaneous dimerization and facilitates the subsequent interaction of the dimer with estrogen response elements (EREs) located within target genes. The estrogen-receptor–ligand complex also leads to binding of various coregulator proteins that vary with . . . [Full Text of this Article]

 

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