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Volume 348:1284-1286 March 27, 2003 Number 13
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Atrial Fibrillation — Rate versus Rhythm Control

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 by The Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) Investigators
-Related Article
 by Van Gelder, I. C.
-PubMed Citation
To the Editor: The authors of the recently published Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) trial (Dec. 5 issue)1 conclude that rhythm control offers no advantage over rate control, although they saw a trend toward improved survival in the rate-control group. Because of the design of the trial, antiarrhythmic drugs were used primarily in the rhythm-control group. However, there is an important difference between the two study groups that was not addressed by the authors. The proportion of patients using beta-blocking drugs in the rhythm-control group was significantly smaller than that in the rate-control group, whether they were . . . [Full Text of this Article]


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