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Previous Volume 348:1365-1375 April 3, 2003 Number 14 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Acute and chronic neurodegenerative diseases are illnesses associated with high morbidity and mortality, and few or no effective options are available for their treatment. A characteristic of many neurodegenerative diseases — which include stroke, brain trauma, spinal cord injury, amyotrophic lateral sclerosis (ALS), Huntington's disease, Alzheimer's disease, and Parkinson's disease — is neuronal-cell death.¹ Given that central nervous system tissue has very limited, if any, regenerative capacity, it is of utmost importance to limit the damage caused by neuronal death.^2,3,4,5 During the past decade, considerable progress has been made in understanding the process of cell death.⁶ In this article, I . . . [Full Text of this Article]

Types of Cell Death

Necrosis

Apoptosis

Mechanisms of Programmed Cell Death

Caspase Family

Role of the Bcl-2 Family in Regulating Release of Mitochondrial Cytochrome c

Inhibitors of Apoptosis

Caspases in Neurologic Diseases

Acute Neurologic Diseases

Chronic Neurodegenerative Diseases

            ALS

            Huntington's Disease

Minocycline

Contagious Apoptosis ("The Kindergarten Effect")

Chronic Caspase Activation and Cell Dysfunction

Conclusions

Source Information

From the Neuroapoptosis Laboratory, Division of Cerebrovascular Surgery, Department of Neurosurgery, Brigham and Women's Hospital and Harvard Medical School, Boston.

Address reprint requests to Dr. Friedlander at the Department of Neurosurgery, Brigham and Women's Hospital, 75 Francis St., Boston, MA 02115, or at rfriedlander@rics.bwh.harvard.edu.

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