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Previous Volume 348:1393-1401 April 3, 2003 Number 14 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text PDF PDA Full Text Purchase this article Editorial by Drazen, J. M. Letters Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited E-mail When Letters Appear PubMed Citation

Each year, about 150,000 people in the United States have acute lung injury or its most severe form, the acute respiratory distress syndrome — devastating lung diseases associated with a mortality rate of between 30 and 50 percent. Despite the severe lung injury, pulmonary function in most survivors returns nearly to normal within 6 to 12 months. Unfortunately, the search for effective treatments to keep patients alive while their lungs heal has lagged behind the substantial progress in basic research. Almost all the treatments that have been tested in clinical trials have not worked.^1,2

After years of bad news, the . . . [Full Text of this Article]

Background

The Tidal-Volume Study

Related Studies

Initial Reaction to the Tidal-Volume Study

Concern about Informed Consent

Concerns about Study Design and Patient Safety

The Response by the NHLBI

The Views of the Expert Panel

The Investigation by the OHRP

The Controversy and Clinical Practice

Resolving the Controversy

Related Letters:

Protection of Research Subjects
Kaufman J. L., Bateman B. T., Meyers P. M., Schumacher H. C., Berger J. T., Karlawish J. H.T., Campbell D. J., Karnad A., Sudbo J., Miller F. G., Rosenstein D. L., Tremaine W. J., Noble J. H. Jr., Sharav V. H., Pesando J. M., Drazen J. M.
Extract | Full Text | PDF  
N Engl J Med 2003; 349:188-192, Jul 10, 2003. Correspondence

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