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Volume 348:1402-1405 April 3, 2003 Number 14
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A Human Papillomavirus Type 16 Vaccine

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 by Koutsky, L. A.
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 by Stanberry, L. R.
-PubMed Citation
To the Editor: Koutsky et al. (Nov. 21 issue)1 report the results of a primary efficacy analysis in a controlled trial of human papillomavirus type 16 (HPV-16) vaccine that includes less than two thirds of all randomized study subjects. To better ascertain the comparability of the two study groups, we are interested in knowing the balance of other risk factors for cervical cancer, such as socioeconomic status, seropositivity for the human immunodeficiency virus (HIV), and use of oral contraceptives. In addition, the investigators excluded a substantial high-risk group (those who reported more than five male sex partners during their lifetime) . . . [Full Text of this Article]




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