The sonic hedgehog (SHH) gene is a human homologue of the drosophilagene encoding inductive signals involved in patterning the earlyembryo and which is highly functionally conserved in many species.1The gene was mapped to chromosome 7 (7q36), the locus for thegene involved in holoprosencephaly (HPE3).2SHH mutations maycause the failure of cerebral hemispheres to separate into distinctleft and right halves, leading to holoprosencephaly, which isone of the most common developmental anomalies of the forebrainand midface in humans.3 Although the majority of cases of holoprosencephalyare sporadic, familial cases are . . . [Full Text of this Article]
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From the Reproductive Genetics Institute, Chicago.
Address reprint requests to Dr. Kuliev at 2825 N. Halsted St., Chicago, IL 60657, or at anverkuliev@hotmail.com.
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