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Volume 348:1806-1809 May 1, 2003 Number 18
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Antiretroviral Therapy Where Resources Are Limited
Steven J. Reynolds, M.D., M.P.H., John G. Bartlett, M.D., Thomas C. Quinn, M.D., Chris Beyrer, M.D., M.P.H., and Robert C. Bollinger, M.D., M.P.H.

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In the State of the Union address of January 2003, President George W. Bush announced an unprecedented five-year, $15 billion Emergency Plan for AIDS Relief1 to provide highly active antiretroviral therapy (HAART) to up to 2 million patients infected with the human immunodeficiency virus (HIV) in Africa and the Caribbean. Such efforts are urgently needed to offer hope to the more than 24 million HIV-infected persons living in settings where medical and economic resources are limited. The availability of generic HAART formulations has facilitated efforts mediated by the Joint United Nations Programme on HIV/AIDS (UNAIDS) to encourage multinational pharmaceutical manufacturers . . . [Full Text of this Article]

The Need for Trained HIV Care Providers

Infrastructure Requirements for the Use of HAART

Antiretroviral Resistance

Improving Treatment Guidelines

Providing HAART

HIV Therapy Combined with Primary Care and Prevention

The Priorities


Source Information

From the Division of Infectious Diseases, Johns Hopkins Medical School, Baltimore (S.J.R., J.G.B., R.C.B.); the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md. (T.C.Q.); and the Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore (C.B.).


Related Letters:

The AIDS Pandemic
Fielder J. F., Gribble R. K., Mujeeb S. A., Altaf A., Reynolds S. J., Quinn T. C., Bollinger R. C.
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N Engl J Med 2003; 349:814-815, Aug 21, 2003. Correspondence

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