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Correspondence
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Volume 348:1821-1822 May 1, 2003 Number 18
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Reversible Dementia Due to Thalidomide Therapy for Multiple Myeloma

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To the Editor: Thalidomide is used to treat multiple myeloma because of its apoptotic1 and antiangiogenic2 properties. Common side effects of thalidomide in patients with multiple myeloma include sedation and peripheral neuropathy.3 We describe a case of reversible dementia due to thalidomide therapy for multiple myeloma.

A 66-year-old man with a history of coronary artery disease received a diagnosis of multiple myeloma in August 2001. In April 2002, he began a chemotherapy regimen of thalidomide (200 mg orally once a day) and dexamethasone (40 mg orally once a day on days 1 through 4, 9 through 12, and 17 through . . . [Full Text of this Article]



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