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Volume 348:1835-1837 May 8, 2003 Number 19 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Over the past two decades, multiple observational studies have suggested that postmenopausal hormone therapy reduces the risks of osteoporotic fractures and coronary heart disease. On the basis of this evidence, hormone therapy was often recommended for women who were at high risk for fractures and coronary disease. But these recommendations were based entirely on observational evidence, which can sometimes be misleading if the groups being compared have different risk patterns and lifestyles. In the early to mid-1990s, several large, randomized trials were initiated to provide definitive evidence concerning the risks and benefits of hormone therapy for the prevention of disease. . . . [Full Text of this Article]

Source Information

From the Departments of Epidemiology and Biostatistics and of Medicine, University of California, San Francisco, and the San Francisco Veterans Affairs Medical Center, San Francisco.

This article was published at www.nejm.org on March 17, 2003.

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