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Previous Volume 348:167-169 January 9, 2003 Number 2 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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In the sepsis syndrome, a "cytokine storm" unleashes numerous inflammatory mediators that contribute to multiple-organ dysfunction and, frequently, to death. During the past decade, research on how the innate immune system activates these mediators has led to remarkable discoveries, many of which are likely to affect the treatment of sepsis.

The pioneering work of Charles Janeway¹ showed that the innate immune system recognizes pathogen-associated molecular patterns and, as a result, causes the release of powerful mediators that protect against infection. The toll family of receptors has emerged as a front-line mechanism by which cells recognize pathogen-associated molecular patterns in endotoxin, . . . [Full Text of this Article]

Source Information

From the Pulmonary Division, Children's Hospital, Boston.

Address reprint requests to Dr. Gerard at the Pulmonary Division, Children's Hospital, Enders Bldg., Rm. 144, 300 Longwood Ave., Boston, MA 02115, or at craig.gerard@tch.harvard.edu.

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