This Journal feature begins with a case vignette highlightinga common clinical problem. Evidence supporting various strategiesis then presented, followed by a review of formal guidelines,when they exist. The article ends with the author's clinicalrecommendations.
A 45-year-old woman reports having had nightly insomnia foryears. On further questioning, she reports having uncomfortablesensations in her legs when she lies down at night. She describesa feeling of needing to move her legs, which is relieved onlyby getting up and walking around. How should this patient beevaluated and treated?
Cuellar, N. G., Ratcliffe, S. J.
(2008). Restless Legs Syndrome in Type 2 Diabetes: Implications to Diabetes Educators. The Diabetes Educator
34: 218-234
[Abstract][Full Text]
Picchietti, D., Allen, R. P., Walters, A. S., Davidson, J. E., Myers, A., Ferini-Strambi, L.
(2007). Restless Legs Syndrome: Prevalence and Impact in Children and Adolescents The Peds REST Study. Pediatrics
120: 253-266
[Abstract][Full Text]
Gomez-Choco, M.J., Iranzo, A., Blanco, Y., Graus, F., Santamaria, J., Saiz, A.
(2007). Prevalence of restless legs syndrome and REM sleep behavior disorder in multiple sclerosis. Mult Scler
13: 805-808
[Abstract]
Schade, R., Andersohn, F., Suissa, S., Haverkamp, W., Garbe, E.
(2007). Dopamine Agonists and the Risk of Cardiac-Valve Regurgitation. NEJM
356: 29-38
[Abstract][Full Text]
Gamaldo, C. E., Earley, C. J.
(2006). Restless legs syndrome: a clinical update.. Chest
130: 1596-1604
[Abstract][Full Text]
(2006). Ropinirole (Requip) for Restless Legs Syndrome. Obstet Gynecol
107: 176-178
[Full Text]
Alpert, C. C., Tobin, D. P., Dierdorf, S. F.
(2005). Physostigmine for the Acute Treatment of Restless Legs Syndrome. Anesth. Analg.
101: 726-727
[Abstract][Full Text]
Tison, F., Crochard, A., Leger, D., Bouee, S., Lainey, E., El Hasnaoui, A.
(2005). Epidemiology of restless legs syndrome in French adults: A nationwide survey: The INSTANT Study. Neurology
65: 239-246
[Abstract][Full Text]
Thorpy, M. J.
(2005). New paradigms in the treatment of restless legs syndrome. Neurology
64: S28-S33
[Abstract][Full Text]
Rye, D. B.
(2004). Relief in sight for restless legs syndrome. Neurology
63: 2213-2214
[Full Text]
Connor, J. R., Wang, X. S., Patton, S. M., Menzies, S. L., Troncoso, J. C., Earley, C. J., Allen, R. P.
(2004). Decreased transferrin receptor expression by neuromelanin cells in restless legs syndrome. Neurology
62: 1563-1567
[Abstract][Full Text]