FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 348:2103-2109 May 22, 2003 Number 21 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text PDF PDA Full Text Purchase this article Letters Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited E-mail When Letters Appear PubMed Citation

This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when they exist. The article ends with the author's clinical recommendations.

A 45-year-old woman reports having had nightly insomnia for years. On further questioning, she reports having uncomfortable sensations in her legs when she lies down at night. She describes a feeling of needing to move her legs, which is relieved only by getting up and walking around. How should this patient be evaluated and treated?

The Clinical Problem

The Diagnosis

The restless legs syndrome (RLS), also known . . . [Full Text of this Article]

Differential Diagnosis

Strategies and Evidence

Evaluation

Treatment

            Dopaminergic Agents

            Other Agents

            Iron Supplementation

            Patients Undergoing Hemodialysis

            Pregnancy

Areas of Uncertainty

Guidelines

Summary and Recommendations

Source Information

From the Department of Neurology, Johns Hopkins School of Medicine, Baltimore.

Address reprint requests to Dr. Earley at the Johns Hopkins Bayview Medical Center, 5501 Hopkins Bayview Circle, AAC-1B-82, Baltimore, MD 21224.

Related Letters:

Restless Legs Syndrome
Chaudhuri K. R.
Extract | Full Text | PDF  
N Engl J Med 2003; 349:815, Aug 21, 2003. Correspondence

This article has been cited by other articles:

• Connor, J. R., Wang, X.-S., Allen, R. P., Beard, J. L., Wiesinger, J. A., Felt, B. T., Earley, C. J. (2009). Altered dopaminergic profile in the putamen and substantia nigra in restless leg syndrome. Brain 132: 2403-2412 [Abstract] [Full Text]  
• Vilarino-Guell, C., Chai, H., Keeling, B. H., Young, J. E., Rajput, A., Lynch, T., Aasly, J. O., Uitti, R. J., Wszolek, Z. K., Farrer, M. J., Lin, S. -C. (2009). MEIS1 p.R272H IN FAMILIAL RESTLESS LEGS SYNDROME. Neurology 73: 243-245 [Full Text]  
• Parish, J. M. (2009). Sleep-Related Problems in Common Medical Conditions. Chest 135: 563-572 [Abstract] [Full Text]  
• Lettieri, C. J., Eliasson, A. H. (2009). Pneumatic Compression Devices Are an Effective Therapy for Restless Legs Syndrome: A Prospective, Randomized, Double-Blinded, Sham-Controlled Trial. Chest 135: 74-80 [Abstract] [Full Text]  
• Crozier, T. A., Karimdadian, D., Happe, S. (2008). Restless Legs Syndrome and Spinal Anesthesia. NEJM 359: 2294-2296 [Full Text]  
• Colao, A., Galderisi, M., Di Sarno, A., Pardo, M., Gaccione, M., D'Andrea, M., Guerra, E., Pivonello, R., Lerro, G., Lombardi, G. (2008). Increased Prevalence of Tricuspid Regurgitation in Patients with Prolactinomas Chronically Treated with Cabergoline. J. Clin. Endocrinol. Metab. 93: 3777-3784 [Abstract] [Full Text]  
• Cuellar, N. G., Ratcliffe, S. J. (2008). Restless Legs Syndrome in Type 2 Diabetes: Implications to Diabetes Educators. The Diabetes Educator 34: 218-234 [Abstract] [Full Text]  
• Picchietti, D., Allen, R. P., Walters, A. S., Davidson, J. E., Myers, A., Ferini-Strambi, L. (2007). Restless Legs Syndrome: Prevalence and Impact in Children and Adolescents The Peds REST Study. Pediatrics 120: 253-266 [Abstract] [Full Text]  
• Gomez-Choco, M.J., Iranzo, A., Blanco, Y., Graus, F., Santamaria, J., Saiz, A. (2007). Prevalence of restless legs syndrome and REM sleep behavior disorder in multiple sclerosis. Mult Scler 13: 805-808 [Abstract]  
• Schade, R., Andersohn, F., Suissa, S., Haverkamp, W., Garbe, E. (2007). Dopamine Agonists and the Risk of Cardiac-Valve Regurgitation. NEJM 356: 29-38 [Abstract] [Full Text]  
• Gamaldo, C. E., Earley, C. J. (2006). Restless legs syndrome: a clinical update.. Chest 130: 1596-1604 [Abstract] [Full Text]  
• Alpert, C. C., Tobin, D. P., Dierdorf, S. F. (2005). Physostigmine for the Acute Treatment of Restless Legs Syndrome. Anesth. Analg. 101: 726-727 [Abstract] [Full Text]  
• Tison, F., Crochard, A., Leger, D., Bouee, S., Lainey, E., El Hasnaoui, A. (2005). Epidemiology of restless legs syndrome in French adults: A nationwide survey: The INSTANT Study. Neurology 65: 239-246 [Abstract] [Full Text]  
• Thorpy, M. J. (2005). New paradigms in the treatment of restless legs syndrome. Neurology 64: S28-S33 [Abstract] [Full Text]  
• Rye, D. B. (2004). Relief in sight for restless legs syndrome. Neurology 63: 2213-2214 [Full Text]  
• Silber, M. H., Ehrenberg, B. L., Allen, R. P., Buchfuhrer, M. J., Earley, C. J., Hening, W. A., Rye, D. B., Medical Advisory Board of the Restless Legs Syndro, (2004). An Algorithm for the Management of Restless Legs Syndrome. Mayo Clin Proc. 79: 916-922 [Abstract]  
• Connor, J. R., Wang, X. S., Patton, S. M., Menzies, S. L., Troncoso, J. C., Earley, C. J., Allen, R. P. (2004). Decreased transferrin receptor expression by neuromelanin cells in restless legs syndrome. Neurology 62: 1563-1567 [Abstract] [Full Text]  
• (2003). Managing patients with restless legs. DTB 41: 81-83 [Abstract] [Full Text]  
• Chaudhuri, K. R. (2003). Restless Legs Syndrome. NEJM 349: 815-815 [Full Text]