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Editorial
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Volume 348:2249-2250 May 29, 2003 Number 22
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Fusion Inhibition — A Major but Costly Step Forward in the Treatment of HIV-1
Karen T. Tashima, M.D., and Charles C.J. Carpenter, M.D.

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-PubMed Citation
Two studies reported in this issue of the Journal1,2 provide heartening news of the success of a new antiretroviral drug in decreasing plasma human immunodeficiency virus (HIV) RNA levels in patients for whom the available combination antiretroviral regimens are no longer effective. These reports are especially noteworthy in that they describe the first controlled trials of the fusion inhibitor enfuvirtide, a representative of a new class of drugs that prevent the entry of HIV type 1 (HIV-1) into the target cells of the host.3 Enfuvirtide specifically prevents the fusion of the HIV-1 transmembrane (gp41) glycoprotein with the CD4 receptor of . . . [Full Text of this Article]


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From Miriam Hospital, Providence, R.I.


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