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Correspondence
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Volume 348:2363-2364 June 5, 2003 Number 23
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Postmenopausal Hormone Therapy

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 by Grodstein, F.
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To the Editor: The assertion by Grodstein et al. (Feb. 13 issue)1 in their Sounding Board article that confounding due to socioeconomic status is unlikely to explain the different reported associations between postmenopausal hormone therapy and cardiovascular disease in observational studies and in randomized clinical trials rests on flawed assumptions. Among these are the assumptions that the Nurses' Health Study "controlled for educational level and occupation by including only registered nurses" (with some adjustment for husband's educational level) and that the Leisure World study "adjusted for income by recruiting exclusively from a middle-class retirement community."

These three socioeconomic variables — . . . [Full Text of this Article]


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