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Previous Volume 348:2366-2367 June 5, 2003 Number 23 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: The mechanism of spontaneous monozygotic twinning is unknown. However, on the basis of observations first made 15 years ago, it is now generally accepted that all forms of assisted conception increase the rate of zygotic splitting.^1,2,3 The true incidence of zygotic splitting is unknown in a substantial proportion of twins, because same-sex dizygotic twins cannot be differentiated from dichorionic monozygotic twins by either antepartum ultrasonography⁴ or postpartum clinical examination.

Single-embryo transfers are currently considered to be a means for minimizing the risk of multiple births with in vitro fertilization. In order to assess the risk of zygotic . . . [Full Text of this Article]

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• Gjerris, A.C., Loft, A., Pinborg, A., Christiansen, M., Tabor, A. (2009). The effect of a 'vanishing twin' on biochemical and ultrasound first trimester screening markers for Down's syndrome in pregnancies conceived by assisted reproductive technology. Hum Reprod 24: 55-62 [Abstract] [Full Text]  
• Vitthala, S., Gelbaya, T.A., Brison, D.R., Fitzgerald, C.T., Nardo, L.G. (2009). The risk of monozygotic twins after assisted reproductive technology: a systematic review and meta-analysis. Hum Reprod Update 15: 45-55 [Abstract] [Full Text]  
• Aston, K I, Peterson, C M, Carrell, D T (2008). Monozygotic twinning associated with assisted reproductive technologies: a review. Reproduction 136: 377-386 [Abstract] [Full Text]  
• Hyden-Granskog, C., Unkila-Kallio, L., Halttunen, M., Tiitinen, A. (2005). Single embryo transfer is an option in frozen embryo transfer. Hum Reprod 20: 2935-2938 [Abstract] [Full Text]