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Correspondence
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Volume 348:2472-2474 June 12, 2003 Number 24
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The Presenting Manifestations of Lyme Disease and the Outcomes of Treatment

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To the Editor: A trial of vaccination against Lyme disease provided an opportunity for us to determine the relative frequencies of the presenting manifestations of Lyme disease and the outcomes of treatment in a large population.1 Our goal was to identify all cases of Borrelia burgdorferi infection that occurred among the 10,936 participants in 10 states where the infection is endemic during the 20-month study period.

Of the 1917 participants who were evaluated for Lyme disease, 269 met the prospectively defined criteria for definite, possible, or asymptomatic infection.1 After completion of the study, post hoc analyses were performed for patients . . . [Full Text of this Article]


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