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Previous Volume 348:2568-2570 June 19, 2003 Number 25 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Celiac disease is an immune-mediated enteropathy triggered by the ingestion of gluten-containing grains (including wheat, rye, and barley) in genetically susceptible persons. The disease is associated with HLA-DQ2 in 90 to 95 percent of cases and with HLA-DQ8 in 5 to 10 percent of cases and is self-perpetuating in the continued presence of gluten.¹ It is the interplay between genes (both HLA and other types) and environment (i.e., gluten) that leads to the intestinal damage that is typical of the disease.² Under physiologic circumstances, this interplay is prevented by competent intercellular tight junctions, structures that limit the passage of macromolecules . . . [Full Text of this Article]

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From the Center for Celiac Research and Mucosal Biology Research Center, University of Maryland School of Medicine, Baltimore.

Related Letters:

Screening for Celiac Disease
Lebwohl B., Green P. H.R., Mäki M., Mustalahti K., Knip M., Fasano A.
Extract | Full Text | PDF  
N Engl J Med 2003; 349:1673-1674, Oct 23, 2003. Correspondence

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