FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 348:2583-2584 June 19, 2003 Number 25 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text PDF PDA Full Text Purchase this article Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited E-mail When Letters Appear PubMed Citation

To the Editor: Studies of hereditary inflammatory disorders have identified novel genes and pathways that may be involved in inflammation and apoptosis generally. Mutations in one such gene, variously named NALP3, CIAS1, and PYPAF1, were recently identified as the cause of the Muckle–Wells syndrome and the familial cold autoinflammatory syndrome¹ and have lately also been associated with neonatal-onset multisystem inflammatory disease.² Interleukin-1 is a key proinflammatory cytokine that contributes to increased synthesis of serum amyloid A protein by hepatocytes during the acute-phase response. The availability of a recombinant interleukin-1–receptor antagonist for clinical use enabled us to undertake a trial of . . . [Full Text of this Article]

This article has been cited by other articles:

• Dostert, C., Petrilli, V., Van Bruggen, R., Steele, C., Mossman, B. T., Tschopp, J. (2008). Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica. Science 320: 674-677 [Abstract] [Full Text]  
• Watanabe, H., Gehrke, S., Contassot, E., Roques, S., Tschopp, J., Friedmann, P. S., French, L. E., Gaide, O. (2008). Danger Signaling through the Inflammasome Acts as a Master Switch between Tolerance and Sensitization. J. Immunol. 180: 5826-5832 [Abstract] [Full Text]  
• Kastbom, A., Verma, D., Eriksson, P., Skogh, T., Wingren, G., Soderkvist, P. (2008). Genetic variation in proteins of the cryopyrin inflammasome influences susceptibility and severity of rheumatoid arthritis (The Swedish TIRA project). Rheumatology (Oxford) 47: 415-417 [Abstract] [Full Text]  
• Martinon, F. (2008). Detection of immune danger signals by NALP3. J. Leukoc. Biol. 83: 507-511 [Abstract] [Full Text]  
• Farasat, S., Aksentijevich, I., Toro, J. R. (2008). Autoinflammatory Diseases: Clinical and Genetic Advances. Arch Dermatol 144: 392-402 [Abstract] [Full Text]  
• Stehlik, C., Dorfleutner, A. (2007). COPs and POPs: Modulators of Inflammasome Activity. J. Immunol. 179: 7993-7998 [Abstract] [Full Text]  
• Kuijk, L. M, Govers, A. M A P, Hofhuis, W. J D, Frenkel, J. (2007). Effective treatment of a colchicine-resistant familial Mediterranean fever patient with anakinra. Ann Rheum Dis 66: 1545-1546 [Full Text]  
• Furst, D E, Breedveld, F C, Kalden, J R, Smolen, J S, Burmester, G R, Sieper, J, Emery, P, Keystone, E C, Schiff, M H, Mease, P, van Riel, P L C M, Fleischmann, R, Weisman, M H, Weinblatt, M E (2007). Updated consensus statement on biological agents for the treatment of rheumatic diseases, 2007. Ann Rheum Dis 66: iii2-iii22 [Full Text]  
• Lachmann, H. J., Goodman, H. J.B., Gilbertson, J. A., Gallimore, J. R., Sabin, C. A., Gillmore, J. D., Hawkins, P. N. (2007). Natural History and Outcome in Systemic AA Amyloidosis. NEJM 356: 2361-2371 [Abstract] [Full Text]  
• Lequerre, T., Vittecoq, O., Saugier-Veber, P., Goldenberg, A., Patoz, P., Frebourg, T., Le Loet, X. (2007). A cryopyrin-associated periodic syndrome with joint destruction. Rheumatology (Oxford) 46: 709-714 [Abstract] [Full Text]  
• Jin, Y., Mailloux, C. M., Gowan, K., Riccardi, S. L., LaBerge, G., Bennett, D. C., Fain, P. R., Spritz, R. A. (2007). NALP1 in Vitiligo-Associated Multiple Autoimmune Disease. NEJM 356: 1216-1225 [Abstract] [Full Text]  
• Molnarfi, N., Gruaz, L., Dayer, J.-M., Burger, D. (2007). Opposite Regulation of IL-1beta and Secreted IL-1 Receptor Antagonist Production by Phosphatidylinositide-3 Kinases in Human Monocytes Activated by Lipopolysaccharides or Contact with T Cells. J. Immunol. 178: 446-454 [Abstract] [Full Text]  
• Leslie, K. S., Lachmann, H. J., Bruning, E., McGrath, J. A., Bybee, A., Gallimore, J. R., Roberts, P. F., Woo, P., Grattan, C. E., Hawkins, P. N. (2006). Phenotype, Genotype, and Sustained Response to Anakinra in 22 Patients With Autoinflammatory Disease Associated With CIAS-1/NALP3 Mutations. Arch Dermatol 142: 1591-1597 [Abstract] [Full Text]  
• Touitou, I, Perez, C, Dumont, B, Federici, L, Jorgensen, C (2006). Refractory auto-inflammatory syndrome associated with digenic transmission of low-penetrance tumour necrosis factor receptor-associated periodic syndrome and cryopyrin-associated periodic syndrome mutations.. Ann Rheum Dis 65: 1530-1531 [Full Text]  
• Pucino, F. Jr., Harbus, P. T., Goldbach-Mansky, R. (2006). Use of biologics in rheumatoid arthritis: Where are we going?. Am J Health Syst Pharm 63: S19-S41 [Abstract] [Full Text]  
• Goldbach-Mansky, R., Dailey, N. J., Canna, S. W., Gelabert, A., Jones, J., Rubin, B. I., Kim, H. J., Brewer, C., Zalewski, C., Wiggs, E., Hill, S., Turner, M. L., Karp, B. I., Aksentijevich, I., Pucino, F., Penzak, S. R., Haverkamp, M. H., Stein, L., Adams, B. S., Moore, T. L., Fuhlbrigge, R. C., Shaham, B., Jarvis, J. N., O'Neil, K., Vehe, R. K., Beitz, L. O., Gardner, G., Hannan, W. P., Warren, R. W., Horn, W., Cole, J. L., Paul, S. M., Hawkins, P. N., Pham, T. H., Snyder, C., Wesley, R. A., Hoffmann, S. C., Holland, S. M., Butman, J. A., Kastner, D. L. (2006). Neonatal-Onset Multisystem Inflammatory Disease Responsive to Interleukin-1{beta} Inhibition. NEJM 355: 581-592 [Abstract] [Full Text]  
• Sutterwala, F. S., Ogura, Y., Zamboni, D. S., Roy, C. R., Flavell, R. A. (2006). NALP3: a key player in caspase-1 activation. Innate Immunity 12: 251-256 [Abstract]  
• Rynne, M, Maclean, C, Bybee, A, McDermott, M F, Emery, P (2006). Hearing improvement in a patient with variant Muckle-Wells syndrome in response to interleukin 1 receptor antagonism. Ann Rheum Dis 65: 533-534 [Abstract] [Full Text]  
• Seitz, M, Kamgang, R K, Simon, H U, Villiger, P M (2005). Therapeutic interleukin (IL) 1 blockade normalises increased IL1{beta} and decreased tumour necrosis factor {alpha} and IL10 production in blood mononuclear cells of a patient with CINCA syndrome. Ann Rheum Dis 64: 1802-1803 [Full Text]  
• Bihl, T, Vassina, E, Boettger, M K, Goldbach-Mansky, R, Seitz, M, Villiger, P M, Simon, H U (2005). The T348M mutated form of cryopyrin is associated with defective lipopolysaccharide-induced interleukin 10 production in CINCA syndrome. Ann Rheum Dis 64: 1380-1381 [Full Text]  
• Stack, J. H., Beaumont, K., Larsen, P. D., Straley, K. S., Henkel, G. W., Randle, J. C. R., Hoffman, H. M. (2005). IL-Converting Enzyme/Caspase-1 Inhibitor VX-765 Blocks the Hypersensitive Response to an Inflammatory Stimulus in Monocytes from Familial Cold Autoinflammatory Syndrome Patients. J. Immunol. 175: 2630-2634 [Abstract] [Full Text]  
• Alexander, T, Klotz, O, Feist, E, Ruther, K, Burmester, G-R, Pleyer, U (2005). Successful treatment of acute visual loss in Muckle-Wells syndrome with interleukin 1 receptor antagonist. Ann Rheum Dis 64: 1245-1246 [Full Text]  
• Ramos, E., Arostegui, J. I., Campuzano, S., Rius, J., Bousono, C., Yague, J. (2005). Positive clinical and biochemical responses to anakinra in a 3-yr-old patient with cryopyrin-associated periodic syndrome (CAPS). Rheumatology (Oxford) 44: 1072-1073 [Full Text]  
• Hu, X., Ho, H. H., Lou, O., Hidaka, C., Ivashkiv, L. B. (2005). Homeostatic Role of Interferons Conferred by Inhibition of IL-1-Mediated Inflammation and Tissue Destruction. J. Immunol. 175: 131-138 [Abstract] [Full Text]  
• Smolen, J S, Steiner, G, Aringer, M (2005). Anti-cytokine therapy in systemic lupus erythematosus. Lupus 14: 189-191 [Abstract]  
• Kastner, D. L. (2005). Hereditary Periodic Fever Syndromes. ASH Education Book 2005: 74-81 [Abstract] [Full Text]  
• Lee, J.-K., Kim, S.-H., Lewis, E. C., Azam, T., Reznikov, L. L., Dinarello, C. A. (2004). Differences in signaling pathways by IL-1{beta} and IL-18. Proc. Natl. Acad. Sci. USA 101: 8815-8820 [Abstract] [Full Text]  
• Dowds, T. A., Masumoto, J., Zhu, L., Inohara, N., Nunez, G. (2004). Cryopyrin-induced Interleukin 1{beta} Secretion in Monocytic Cells: ENHANCED ACTIVITY OF DISEASE-ASSOCIATED MUTANTS AND REQUIREMENT FOR ASC. J. Biol. Chem. 279: 21924-21928 [Abstract] [Full Text]  
• Grateau, G. (2004). Clinical and genetic aspects of the hereditary periodic fever syndromes. Rheumatology (Oxford) 43: 410-415 [Abstract] [Full Text]