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Previous Volume 348:2669-2677 June 26, 2003 Number 26 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Presentation of Case

A nine-year-old girl was admitted to the hospital because of hepatosplenomegaly and pain in the thigh.

The patient had been well until three years earlier, when she began to have frequent episodes of epistaxis. Two years before admission, mild abdominal distention developed. Periodic examinations by her physician were reported to have revealed no abnormalities. Two months before admission, the abdominal distention worsened but was not accompanied by abdominal pain. Physical examination revealed hepatosplenomegaly. An abdominal ultrasonographic study confirmed the presence of hepatosplenomegaly, without evidence of portal-vein thrombosis (Figure 1). The results of liver-function tests were normal or nearly . . . [Full Text of this Article]

Differential Diagnosis

Anatomical Abnormalities, Congestion, and Infection

Hematologic Diseases

Infiltrative Processes

            Malignant Neoplasms

            Histiocytic Disorders

            Gaucher's Disease

Clinical Diagnosis

Dr. Eric C. Larsen's Diagnosis

Pathological Discussion

Anatomical Diagnosis

Source Information

From the Division of Pediatric Hematology/Oncology, Dartmouth Hitchcock Medical Center, and the Department of Pediatrics, Dartmouth Medical School, Lebanon, N.H. (E.C.L.); and the Departments of Radiology (S.A.C.) and Pathology (A.E.R.), Massachusetts General Hospital and Harvard Medical School, Boston.

Related Letters:

Case 20-2003: Gaucher's Disease
Beutler E., Sims K., Ebb D.
Extract | Full Text | PDF  
N Engl J Med 2004; 350:416-417, Jan 22, 2004. Correspondence

This article has been cited by other articles:

• Beutler, E., Sims, K., Ebb, D. (2004). Case 20-2003: Gaucher's Disease. NEJM 350: 416-417 [Full Text]