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Previous Volume 348:260-264 January 16, 2003 Number 3 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Lurbe et al. (Sept. 12 issue)¹ report that the normal decrease in nocturnal blood pressure may be blunted before the development of microalbuminuria in patients with type 1 diabetes. The authors' suggestion that subtly increased blood pressure is the mechanism behind the nephropathy may be an oversimplification. Although average blood pressure was slightly higher in the patients in whom microalbuminuria subsequently developed, hyperglycemia and higher heart rates were also more common in these patients. Altered autonomic tone may be associated with all these observations, including the increased rate of microalbuminuria.

In patients with diabetes, nocturnal heart-rate variability . . . [Full Text of this Article]

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