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Previous Volume 348:264-265 January 16, 2003 Number 3 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: In the report by Prié et al. (Sept. 26 issue)¹ indicating that inactivating mutations in the sodium–phosphate cotransporter gene, NPT2a, are associated with renal phosphate wasting and bone demineralization, the data on expression do not support a dominant negative effect of the V147M mutation. As the authors themselves acknowledge, coinjection of 10 ng of wild-type RNA and 10 ng of mutant (V147M) RNA yielded a phosphate-induced current "similar to that in oocytes expressing 10 ng of wild-type NPT2a RNA alone." The comparison of this current with that produced by injection of 20 ng of wild-type RNA is . . . [Full Text of this Article]

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