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Volume 348:468-470 January 30, 2003 Number 5
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Polymorphisms of Adrenergic Receptors and the Risk of Heart Failure

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by Small, K. M.
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To the Editor: The interesting study by Small et al. (Oct. 10 issue)1 showed that two potentially synergistic adrenergic-receptor polymorphisms are associated with a risk of congestive heart failure. Since this may indeed give rise to genotype-targeted intervention studies, one important point deserves attention. Although the polymorphism involving the substitution of glycine for arginine at position 389 (Arg389Gly) of the {beta}1-adrenergic receptor has clearly been shown to be functional in vitro, data on its consequences in vivo are conflicting.2 Moreover, there is high sequence variability in the gene encoding the {beta}1-adrenergic receptor, with at least 18 single-nucleotide polymorphisms leading to . . . [Full Text of this Article]



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