The promise of pharmacogenetics, the study of the role of inheritancein the individual variation in drug response, lies in its potentialto identify the right drug and dose for each patient. Even thoughindividual differences in drug response can result from theeffects of age, sex, disease, or drug interactions, geneticfactors also influence both the efficacy of a drug and the likelihoodof an adverse reaction.1,2,3 This article briefly reviews conceptsthat underlie the emerging fields of pharmacogenetics and pharmacogenomics,with an emphasis on the pharmacogenetics of drug metabolism.Although only a few examples will be provided to . . . [Full Text of this Article]
Pharmacogenetics of Drug Metabolism
Pharmacogenetics of Phase I Drug Metabolism
Pharmacogenetics of Phase II Drug Metabolism
From Pharmacogenetics to Pharmacogenomics
Conclusions
Source Information
From the Departments of Molecular Pharmacology and Experimental Therapeutics and Medicine, Mayo Medical School, Mayo Clinic, and Mayo Foundation, Rochester, Minn.
Address reprint requests to Dr. Weinshilboum at the Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Medical School–Mayo Clinic–Mayo Foundation, Rochester, MN 55905, or at weinshilboum.richard@mayo.edu.
Related Letters:
Pharmacogenetics
Padrini R., Ferrari M., Carnes M., Noah L., Weinshilboum R., Evans W. E., McLeod H. L., Goldstein D. B., Vallance P.
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N Engl J Med 2003;
348:2041-2043, May 15, 2003.
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