In this issue of the Journal, Aspelin et al.1 report findingsfrom a prospective, randomized, double-blind trial that comparediodixanol, a third-generation, iso-osmolar, dimeric, nonioniciodinated contrast agent, with iohexol, a low-osmolar, monomeric,nonionic contrast agent. The use of iodixanol resulted in significantlyfewer nephrotoxic effects in high-risk patients undergoing arteriographythan iohexol did — findings that are important becausea beneficial effect of this iso-osmolar agent on renal functionhad not previously been conclusively demonstrated in a randomizedstudy.
Before the late 1960s, all iodinated contrast agents used forradiologic imaging were ionic monomers with an ionizing carboxylgroup . . . [Full Text of this Article]
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From the Department of Radiology, University of Texas Houston Medical School, Houston.
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