FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 348:564 February 6, 2003 Number 6 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text PDF PDA Full Text Purchase this article Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited E-mail When Letters Appear Related Article by Kitabwalla, M. PubMed Citation

To the Editor: The article on RNA interference by Kitabwalla and Ruprecht (Oct. 24 issue)¹ is most timely in view of the excitement produced by the recent demonstration that small interfering RNAs (siRNAs) have important functions in RNA cleavage involved in host defense against viruses and in the destruction of deleterious messenger RNAs of other kinds. However, I believe the authors err in describing Dicer as an RNA-dependent RNA polymerase limited to plants and drosophila (in the legend to Figure 1 in their article). Dicer was initially described as the endogenous ribonuclease that generates siRNAs from longer double-stranded RNAs² and . . . [Full Text of this Article]

HOME  |  SUBSCRIBE  |  SEARCH  |  CURRENT ISSUE  |  PAST ISSUES  |  COLLECTIONS  |  PRIVACY  |  HELP  |  beta.nejm.org Comments and questions? Please contact us. The New England Journal of Medicine is owned, published, and copyrighted © 2008 Massachusetts Medical Society. All rights reserved.